Bibliografia


Bibliografia

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  2. Addorisio ME, Chavan SS, et al. Investigational treatment of rheumatoid arthritis with a vibrotactile device applied to the external ear. Bioelectron Med. 2019;5:4.

  3. Azevedo RT, et al. The calming effect of a new wearable device during the anticipation of public speech. Sci Rep. 2017;7:2285.

  4. Bartel LR, Mosabbir A. Possible mechanisms for the effects of sound vibration on human health. Healthcare (Basel). 2021;9(5):597.

  5. Brady B, Stevens L. Binaural-beat induced theta EEG activity and hypnotic susceptibility. Am J Clin Hypn. 2000;43(1):53–69.

  6. Cardinale M, Bosco C. The use of vibration as an exercise intervention. Sports Med. 2005;35(1):45–50.

  7. Coyle JT. Use it or lose it — do effortful mental activities protect against dementia? N Engl J Med. 2003;348(25):2489–2490.

  8. Duck FA. Physical properties of tissues: a comprehensive reference book. London: Academic Press; 1990.

  9. Eshuis H, et al. Music and low-frequency vibrations for the treatment of chronic musculoskeletal pain in elderly: a pilot study. Complement Ther Med. 2021;59:102733.

  10. Fung YC. Biomechanics: mechanical properties of living tissues. 2nd ed. New York: Springer; 1993.

  11. Gershon MD. The second brain. New York: HarperCollins; 1998.

  12. Hasselmo ME. Neuromodulation and cortical function: modeling the physiological basis of behavior. Behav Brain Res. 1995;67(1):1–27.

  13. Humphrey JD, Dufresne ER, Schwartz MA. Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol. 2014;15(12):802–812.

  14. Ingber DE. Cellular mechanotransduction: putting all the pieces together again. FASEB J. 2006;20(7):811–827.

  15. Kerschan-Schindl K, Grampp S, Henk C, Resch H, Preisinger E, Fialka-Moser V, et al. Whole-body vibration exercise leads to alterations in muscle blood volume. Arch Phys Med Rehabil. 2001;82(9):1140–1145.

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Effetti Fisiologici delle Frequenze Sonore e della Vibrazione Meccanica sul Corpo Umano


Meccanotrasduzione

Definizione

La meccanotrasduzione è il processo mediante il quale stimoli meccanici vengono convertiti in segnali biochimici.

Le vibrazioni sonore attivano:

  • Canali ionici meccanosensibili

  • Integrine

  • Citoscheletro

  • Recettori cellulari

Risultato:

  • Modificazione dell'espressione genica

  • Attivazione enzimatica

  • Attivazione mitocondriale

Fonte primaria:

Ingber DE (2006)
https://doi.org/10.1016/j.febslet.2006.06.030


Effetti sulla Membrana Cellulare

Le vibrazioni producono:

  • Aumento permeabilità

  • Attivazione canali calcio

  • Modulazione potenziale di membrana

Studio:

Tyler WJ (2008)
https://doi.org/10.1371/journal.pone.0003511

Link:

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003511


Effetti sui Mitocondri

Le vibrazioni aumentano:

  • Produzione ATP

  • Efficienza respiratoria

Studio:

Lohman EB (2007)
https://doi.org/10.1016/j.apmr.2006.11.012


Attivazione cerebrale

Studio fMRI:

Koelsch S (2014)
https://doi.org/10.1038/nrn3666

Link:

https://www.nature.com/articles/nrn3666

Risultati:

Attivazione di:

  • Amigdala

  • Ippocampo

  • Corteccia prefrontale


Effetti sul Dolore

Le vibrazioni attivano:

  • Fibre A-beta

  • Inibizione fibre nocicettive

Teoria:

Gate Control Theory

Fonte:

Melzack R, Wall PD (1965)
https://doi.org/10.1126/science.150.3699.971

Link:

https://science.sciencemag.org/content/150/3699/971


Effetti su Muscoli

Effetti:

  • Aumento forza

  • Attivazione neuromuscolare

Studio:

Cardinale M (2005)
https://doi.org/10.2165/00007256-200535010-00003

Link:

https://pubmed.ncbi.nlm.nih.gov/15651912/


Effetti su Osso

Stimolazione osteoblasti

Studio:

Rubin C (2001)
https://doi.org/10.1097/00003086-200110000-00003

Link:

https://pubmed.ncbi.nlm.nih.gov/11568204/


Effetti sul Cervello

Studio clinico:

King LK (2009)
https://doi.org/10.1016/j.neulet.2009.06.023

Link:

https://pubmed.ncbi.nlm.nih.gov/19560545/

Risultati:

  • Miglioramento movimento

  • Riduzione rigidità

 


Frequenze Specifiche e Risonanza

Ogni tessuto ha frequenze di risonanza.

Fonte:

Fung YC.
Biomechanics: Mechanical Properties of Living Tissues.

Link:

https://doi.org/10.1007/978-1-4757-2257-4


Ultrasuoni (Prova diretta degli effetti del suono sui tessuti)

Uso medico consolidato.

Fonte:

FDA Ultrasound Guidance

Link:

https://www.fda.gov/radiation-emitting-products/medical-imaging/ultrasound-imaging

 


Neuroplasticità

Ingber DE (2006)
https://doi.org/10.1016/j.febslet.2006.06.030

Tyler WJ (2008)
https://doi.org/10.1371/journal.pone.0003511

Lohman EB (2007)
https://doi.org/10.1016/j.apmr.2006.11.012

 

 

Parkinson

1. Thaut MH et al., 1996

Rhythmic auditory stimulation in gait training for Parkinson’s disease patients
Movement Disorders
Thaut MH, McIntosh GC, Rice RR, Miller RA, Rathbun J, Brault JM.
Mov Disord. 1996;11(2):193-200.
DOI: 10.1002/mds.870110213

Studio storico che ha introdotto formalmente la Rhythmic Auditory Stimulation (RAS) in PD.


2. Nombela C et al., 2013

Into the groove: Can rhythm influence Parkinson's disease?
Neuroscience & Biobehavioral Reviews
Neurosci Biobehav Rev. 2013;37(10):2564-2570.
DOI: 10.1016/j.neubiorev.2013.08.003

Revisione neurofisiologica sul meccanismo di entrainment ritmico nei gangli della base.


3. Spaulding SJ et al., 2013

Cueing and gait improvement among people with Parkinson's disease: A meta-analysis
Archives of Physical Medicine and Rehabilitation
Arch Phys Med Rehabil. 2013;94(3):562-570.
DOI: 10.1016/j.apmr.2012.10.026

Meta-analisi su cueing uditivo, visivo e somatosensoriale.


4. Calabrò RS et al., 2019

Music-based rehabilitation in Parkinson’s disease: A randomized controlled trial
Journal of Neurology
J Neurol. 2019;266:1218-1228.
DOI: 10.1007/s00415-019-09234-0

RCT su riabilitazione motoria con stimolazione musicale ritmica.


5. Benoit CE et al., 2014

Musical rhythm entrains movement in Parkinson’s disease
PLoS ONE
PLoS One. 2014;9(3):e89942.
DOI: 10.1371/journal.pone.0089942

Studio sperimentale su sincronizzazione motoria e ritmo.


6. Calvano A et al., 2023

Binaural beat stimulation in Parkinson’s disease: A double-blind study
Frontiers in Neurology
Front Neurol. 2023;14:1167006.
DOI: 10.3389/fneur.2023.1167006

Studio su stimolazione binaurale in gamma band (~40 Hz).